MOTS-c 10mg

MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded by a short open reading frame in the mitochondrial 12S rRNA region. The name refers to “mitochondrial open reading frame of the 12S rRNA-c.”

The commonly referenced human sequence is MRWQEMGYIFYPRKLR. PubChem lists the human peptide at approximately 2,174.6 g/mol with the formula C101H152N28O22S2.

Unlike peptides translated from nuclear genes, MOTS-c originates from a short open reading frame within mitochondrial DNA. This makes it a model for signaling between mitochondrial and nuclear systems.

Published cell and animal studies examine the folate-purine pathway, AICAR and AMPK signaling, nuclear translocation, stress-responsive gene expression and metabolic homeostasis. Much of this work remains preclinical.

The Selected literature section links to the original metabolic-homeostasis report, research on nuclear translocation and metabolic stress, a mechanistic review, and newer mitochondrial-bioenergetics work.

Every batch goes through three layers of quality control. Our manufacturer runs its own QC and has its production independently tested by Janoshik Analytical. Then Vanguard or Janoshik tests every batch we stock again, for identity, HPLC purity, net content and endotoxins before we approve it for sale.

Every approved batch has its lab report on the Test Results page.

We target 99%+ purity by HPLC. The actual purity of each batch is measured independently and published in its lab report, so you can check the result yourself.

Store the sealed lyophilized vial at -20°C, protected from light, and follow the product label and batch documentation. After reconstitution, use controlled refrigerated laboratory storage at 2-8°C within the defined research window and avoid repeated freeze-thaw cycles.